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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
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2009 4
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2011 8
2012 8
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2014 9
2015 9
2016 5
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2018 10
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2020 11
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121 results

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Page 1
STK4 deficiency and EBV-associated lymphoproliferative disorders, emphasis on histomorphology, and review of literature.
Saglam A, Cagdas D, Aydin B, Keles S, Reisli I, Arslankoz S, Katipoglu K, Uner A. Saglam A, et al. Virchows Arch. 2022 Feb;480(2):393-401. doi: 10.1007/s00428-021-03147-w. Epub 2021 Oct 4. Virchows Arch. 2022. PMID: 34604912 Review.
Aberrations of the STK4 gene in humans result in an autosomal recessively inherited primary immunodeficiency. We identified three patients with STK4 deficiency who had presented to our hospital and reviewed their biopsy samples with the goal of detailing the charact …
Aberrations of the STK4 gene in humans result in an autosomal recessively inherited primary immunodeficiency. We identified three pat …
STK4 protein expression pattern follows different trends in endometrioid and serous endometrial adenocarcinoma upon tumor progression.
Govorov I, Attarha S, Kovalevska L, Andersson E, Kashuba E, Mints M. Govorov I, et al. Sci Rep. 2022 Dec 22;12(1):22154. doi: 10.1038/s41598-022-26391-9. Sci Rep. 2022. PMID: 36550267 Free PMC article.
In the present paper, we studied STK4 expression in EC tissues from a large cohort of patients to determine whether STK4 can serve as a marker for the aggressiveness and prognosis of EC. ...The STK4 gene expression was low at both, the mRNA and protein levels …
In the present paper, we studied STK4 expression in EC tissues from a large cohort of patients to determine whether STK4 can s …
Ginsenoside Rh2 attenuates the progression of non-small cell lung cancer by sponging miR-28-5p/STK4 axis and inactivating Wnt/beta-catenin signaling.
Ma J, Zhao D, Yu D, Song W, Yang X, Yin H. Ma J, et al. Cancer Med. 2023 Jun;12(11):12653-12667. doi: 10.1002/cam4.5960. Epub 2023 Apr 20. Cancer Med. 2023. PMID: 37081781 Free PMC article.
Kaplan-Meier Plotter was conducted to analyze the survival rate for different serine/threonine-protein kinase 4 (STK4) expressions with different prognostic risks. immunohistochemistry of STK4 expression in non-tumor and tumor tissues was analyzed from the HPA datab …
Kaplan-Meier Plotter was conducted to analyze the survival rate for different serine/threonine-protein kinase 4 (STK4) expressions wi …
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Li W, Xiao J, Zhou X, Xu M, Hu C, Xu X, Lu Y, Liu C, Xue S, Nie L, Zhang H, Li Z, Zhang Y, Ji F, Hui L, Tao W, Wei B, Wang H. Li W, et al. J Clin Invest. 2015 Nov 2;125(11):4239-54. doi: 10.1172/JCI81203. Epub 2015 Oct 12. J Clin Invest. 2015. PMID: 26457732 Free PMC article.
Moreover, serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6. ...Together, our results suggest that STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC....
Moreover, serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6. ...Together, our results suggest th …
A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC.
Guo X, Zhang Z, Lin C, Ren H, Li Y, Zhang Y, Qu Y, Li H, Ma S, Xia H, Sun R, Zu H, Lin Y, Wang X. Guo X, et al. Autophagy. 2023 May;19(5):1533-1550. doi: 10.1080/15548627.2022.2139922. Epub 2022 Nov 6. Autophagy. 2023. PMID: 36300799 Free PMC article.
In conclusion, we uncover the unique molecular mechanism by which A/(H1N1) pdm09 utilizes autophagy to promote self-replication, and we provide theoretical basics for the analysis of the etiological characteristics of the A/(H1N1) pdm09 pandemic and the development of anti-influe …
In conclusion, we uncover the unique molecular mechanism by which A/(H1N1) pdm09 utilizes autophagy to promote self-replication, and we prov …
Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP. Bata N, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369. doi: 10.1021/acs.jmedchem.1c00804. Epub 2021 Nov 22. J Med Chem. 2022. PMID: 34807584 Free PMC article.
Herein, we report the structure-based design of a series of pyrrolopyrimidine derivatives as STK3 and STK4 inhibitors. In an initial screen, the compounds exhibited low nanomolar potency against both STK3 and STK4. Crystallization of compound 6 with STK4 reve …
Herein, we report the structure-based design of a series of pyrrolopyrimidine derivatives as STK3 and STK4 inhibitors. In an initial …
STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma.
Bai ZY, Peng LS, Li RQ, Peng X, Yang Z. Bai ZY, et al. Aging (Albany NY). 2023 Oct 20;15(20):11286-11297. doi: 10.18632/aging.205127. Epub 2023 Oct 20. Aging (Albany NY). 2023. PMID: 37870765 Free PMC article.
We then used gene set enrichment analysis (GSEA) to explore the mechanisms behind STK4 function in ccRCC. We found that STK4 may play a role in immune regulation interactions. Subsequently, we performed immune infiltration analysis of STK4. The results showed …
We then used gene set enrichment analysis (GSEA) to explore the mechanisms behind STK4 function in ccRCC. We found that STK4 m …
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG. Reiberger T, et al. Nat Protoc. 2015 Aug;10(8):1264-74. doi: 10.1038/nprot.2015.080. Epub 2015 Jul 23. Nat Protoc. 2015. PMID: 26203823 Free PMC article.
In this setting, CCl4 is administered for 12 weeks after tail-vein injection of Cre-expressing adenovirus (adeno-Cre) in Stk4(-/-)Stk3(F/-) (also known as Mst1(-/-)Mst2(F/-); F indicates a floxed allele) mice, and it results in the development of HCC tumors (hepatocarcinog …
In this setting, CCl4 is administered for 12 weeks after tail-vein injection of Cre-expressing adenovirus (adeno-Cre) in Stk4(-/-)Stk …
MST Kinases and Metabolism.
Pombo CM, Iglesias C, Sartages M, Zalvide JB. Pombo CM, et al. Endocrinology. 2019 May 1;160(5):1111-1118. doi: 10.1210/en.2018-00898. Endocrinology. 2019. PMID: 30882881 Review.
Since the discovery of the mammalian sterile twenty (MST) kinase family of proteins (MST1/STK4, MST2/STK3, MST3/STK24, and SOK1/STK25), much has been done that adds to our knowledge of their structure, regulation, and function. ...
Since the discovery of the mammalian sterile twenty (MST) kinase family of proteins (MST1/STK4, MST2/STK3, MST3/STK24, and SOK1/STK25 …
121 results